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These can be subtle but significant signs

Additionally, there are certain classes of medications that hinder healing, including immunosuppressants, corticosteroids, non-steroidal anti-inflammatory drugs (NSAIDs), and anticoagulants

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This results in defects in mitophagy, whereas a large number of dysfunctional mitochondria are not removed in time and excessively accumulate in neuronal cells, which induces a vicious circle-chain reaction (Wong and Holzbaur, 2014)

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