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Beyond direct antioxidant activity, GSH functions as an obligatory cofactor for a family of enzyme systems that are central to cellular defence: glutathione peroxidases (GPx), which reduce peroxides and lipid hydroperoxides using GSH as the reducing substrate

If additional glycemic control is needed, the dose can be increased by 2.5 mg every 4 weeks, and the maximum dose of this drug is 15 mg once a week