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Subsequent research has demonstrated that RSL3 directly binds to and inhibits GPX4, a downstream molecule in the cystine uptake and subsequent GSH (glutathione) synthesis pathway mediated by the system xc - , following the reduction of cystine to cysteine [9]
Developing cell-type-specific SIRT1 regulatorsfor example, hepatocyte-targeted molecules using GalNAc ligands or KC-specific nanoparticlesmay allow targeted activation, while selective inhibition in cells such as activated HSCs could also be explored
Intern Med 165 , 13951400 (2005)
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