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Therefore, the significance of PGAM5 in necroptosis requires further investigation and confirmation

38,39 In the MONICA/KORA study, the overall prevalence of neuropathic pain was 13.3% among diabetes patients, 8.7% in those with impaired glucose tolerance, 4.2% in those with impaired fasting glucose, and 1.2% in individuals with normal glucose tolerance

While phase I and phase II enzymes are majorly responsible for chemically modifying the hydrophobic toxin to make it more hydrophilic, phase III is mostly related to the function of drug efflux performed by those drug transporters, such as the multidrug resistance (MDR) pump