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The four cascades that make up the MAPK pathway are extracellular signal-regulated kinase (ERK) 1/2, p38, c-Jun N-terminal kinase (JNK), and ERK5 ( Figure 8 )

In both cases, FOXO4-DRI did not further enhance these effects

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REDEFINE 1, in adults with overweight or obesity without diabetes, reported 22.7% mean weight loss for the combination at 68 weeks on the on-treatment analysis, with 60% of combination participants reaching at least 20% loss and 23% reaching at least 30% (Aronne et al., 2025)

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