Je nach Wirkstoff und Patientensituation mssen auerdem Pankreatitis, Gallenblasenerkrankungen, schwere gastrointestinale Erkrankungen, Dehydratation mit mglicher Verschlechterung der Nierenfunktion, diabetische Retinopathie, Hypoglykmien bei Kombination mit Insulin oder Sulfonylharnstoffen sowie produktspezifische Gegenanzeigen und Warnhinweise beachtet werden
A higher risk of deficiency is present in patients with malabsorptive syndrome and/or unusually low sun exposure, those who have undergone gastric bypass surgery, or those on prolonged glucocorticoid use (which alters intestinal absorption) ( Cancer patients may have a higher risk of deficiency due to causes of intestinal fat malabsorption (i.e., intestinal surgery, pancreatectomy, gastrectomy) or due to oncologic treatments, such as aromatase inhibitors
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If SCoV2 is targeting GSH biosynthesis as well as TXNRD1 and GPx1 for proteolytic knockdown, in infected cells, the resulting decreases in these critical antioxidant molecules would contribute to increased oxidative stress, NF-B activation and pro-apoptotic signaling (17, 18)
Mol Cell Biol 34:34213434 Acknowledgments We thank current and past colleagues in our laboratories and collaborators for active contribution to the research on NRF2 and cancers
