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By linking skeletal muscle-derived HN to improvements in hepatic metabolism, the study provides evidence for a muscleliver communication axis in obesity and NAFLD

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Of note, IP3 inhibits autophagy through the activation of endoplasmic reticulum (ER) IP3 receptors which induce the release of Ca 2+ leading to the stimulation of the calpain pathway which inhibits autophagy (Chiurillo et al