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Fibroblasts (CAFs) constitute the largest group of nonimmune cells in the TME, and there is increasing evidence that CAFs can regulate glutamine levels in the TME and thus generate energy to promote the tricarboxylic acid cycle (TCA) cycle and supply energy for cancer cell growth [12]

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and Freeman, H

Reliable BAC water use supports safer medication administration

It may be that the modulation of glutamate catabolism serves to maintain the intracellular glutamate/2-oxoglutarate ratios which is known to co-ordinate a number of cellular activities such as growth rate modulation [40]