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NNMT had previously been identified as upregulated in obese adipose tissue, several solid tumours, and ageing tissue more broadly, where its activity correlates with depleted SAM and elevated 1-methylnicotinamide (MNA)

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However, in multicellular organisms the specific (de) phosphorylation of tyrosine residues became more and more the method of choice for regulation of cell division and cell diversity (Lim and Pawson, 2010)