In vitro , dendritic cells and fibroblasts expressing Slc7a11 contribute to extracellular redox regulation through glutathione synthesis and maintain cysteine supply to Slc7a11 -deficient cells, such as lymphocytes
Docking scores were obtained for each molecule that could be successfully docked into the active site of GPx1, and molecules were subsequently ranked based on their Chemgauss4 docking score [33].Only molecules that ranked within the top 150 docking scores (top 10%) for each model (1GP1 or 2F8A) were considered for subsequent pharmacoepidemiological analyses as these drugs were more likely to potently bind to the target and exert their effects [40,41,42,43]
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To visualize small-molecule metabolites localized within TLS, we used matrix-assisted laser desorption/ionization time of flight imaging mass spectrometry and found significant accumulation of glutathione (reduced form: glutathione [GSH], oxidized form: glutathione disulfide [GSSG]) within TLS (Figure 1C)
You may be at risk of vitamin B12 deficiency if you fall into any of the aforementioned categories