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Ramos emphasizes is that this is not a single wall but a layered defense system : a physical barrier (tight junctions and epithelial integrity), a chemical barrier (mucus, enzymes, and stomach acid), a microbial barrier (the gut microbiota acting as an immune modulator), and an immune barrier (the gut-associated lymphoid tissue, or GALT)

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Made up of three amino acids, KPV is known to retain the properties of the much larger alpha-MSH protein including anti-ischemic and anti-inflammatory properties

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