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In clinical trials, the frequency was low and broadly comparable to placebo groups
Choi, M, Kadara H, Zhang J, Parra Cuentas E, Rodriguez Canales J, Gaffney SG, Zhao Z, Behrens C, Fujimoto J, Chow C, Kalhor N, Moran C, Rimm D, Swisher SG , Gibbons DL, Heymach JV, Kaftan E, Townsend J, Lynch TJ, Schlessinger J, Lee JJ, Lifton R, Herbst RS, Wistuba II
In an animal study, Brasil et al
Expression of the clock repressor Period2 (Per2) is inversely correlated with claudin-5 levels, supporting circadian regulation of tight junction dynamics (71)