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K.ReidJ

ES2 is a senolytic peptide that targets FOXO4 CR3 but exhibits relatively poorer selectivity for senescent cells compared to FOXO4-DRI 25 (Table S1)

In obese rodent models, it promotes lipolysis by breaking down stored fats into free fatty acids without stimulating GH pathways such as IGF-1

The AED sequence structurally corresponds to segments found in the alpha-1 chain of type XI collagen, a protein critical for maintaining cartilage integrity and organizing the extracellular matrix