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Amylin and Calcitonin Receptor Pathway Satiety Enhancement Cagrilintide acts as a nonselective agonist of amylin receptors (AMY1R, AMY2R, AMY3R) and calcitonin receptor (CTR), mimicking the satiety-inducing effects of endogenous amylin[3]

The peptide also promotes angiogenesis through increased expression of VEGF and basic fibroblast growth factor (bFGF)

This mechanism differs fundamentally from collagen synthesis pathways targeted by compounds like GHK-Cu

Antioxidant pathway studies: Copper cofactor activity supports superoxide dismutase (SOD), a key enzyme protecting keratinocytes from free radical damage and oxidative stress

Sanacora, G