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doi: 10.1038/s41593-025-02075-1 225 MastrogiacomoF.BergeronC.KishS

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Additionally, the overall quality of evidence for each outcome was evaluated using the GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) framework (Guyatt et al., 2008) which considers factors such as risk of bias, inconsistency, indirectness, imprecision, and publication bias to provide a comprehensive evaluation of the strength of evidence

NO is a vasodilator that acts via cGMP which is produced by SMCs

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