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Principle coordinates analyses (PCoAs) were generated based on the distance and dissimilarity matrices

Based on the clinical trial data and the known mechanism, AOD 9604 does not appear to cause muscle loss

Off-period (weeks 12+) : 4 to 6 weeks off lets baseline NNMT activity reset before the next cycle

TECHNICAL SPECIFICATIONS Product Information Chemical Name: 5-Amino-1-methylquinolinium Common Names: 5-Amino-1MQ, 5-amino-1-methylquinoline, 5 amino 1mq CAS Number: 42464-96-0 Molecular Formula: C10H11N2+ Molecular Weight: 159.21 g/mol Appearance: White to off-white lyophilized powder Purity: 98% (HPLC verified) Storage: Store at room temperature

(Nature, 2014) used an antisense oligonucleotide to knock down NNMT in mice and reported reduced fat-mass gain, better glucose tolerance, and lower liver triglycerides the founding paper for the whole NNMT-inhibitor field