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161 The trials involved adult participants with T2DM aged 18 to 75, conducted across 42 research and medical centers in the United States

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This article is based on previously conducted studies and does not contain any new studies with human participants or animals performed by any of the authors

It plays an essential role in cell communication, tissue regeneration and wound healing

2 Because placebo effects are common in controlled trials conducted with IC/BPS patients, any apparent procedural deviations that could compromise the integrity of randomization or blinding resulted in a rating of increased risk of bias for that particular trial