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This effect is attributed to the activation of PPAR and the consequent suppression of ferritinophagy-induced mitochondrial damage via the cGASSTING1 signaling axis [123]

Haenen, H.E.M.G., Bleijlevens, E., Elzerman, H., Temmink, J.H.M., Koeman, J.H

However, a deeper comprehension of the DA catabolic pathway and how it functions in PD patients will enable the development of more individualized and efficient therapy approaches

In other embodiments, the otic formulations or compositions described herein are administered as a controlled release formulation or compositions, released either continuously or in a pulsatile manner, or variants of both

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