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p38 MAPK-activated kinase phosphorylates many targets involved in actin microfilament dynamics, such as heat-shock protein 27 (Hsp27), activating transcription factor 2 (ATF-2), and LSP-1, 449 which may explain the fact that the p38 MAPK pathway regulates neutrophil chemotaxis

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Targeted therapy resistance, a major clinical challenge, is amenable to intervention via the autophagy-ferroptosis axis, a key determinant of cell fate under stress, through two primary strategies

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Compounded medications are not approved or evaluated by the FDA for safety, effectiveness, or quality and are available by prescription only