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Stimuli-Responsive mRNA vaccines to induce robust CD8 + T cell response via ROS-Mediated innate immunity boosting

The computational approaches demonstrated with paracetamol are being applied broadly to: Enable rapid screening of compound libraries against multiple targets Identify potential off-target effects early in development Support rational design of multi-target drugs for complex diseases Facilitate drug repositioning through new therapeutic application identification For personalized medicine, complete target profiles enable better individual response predictions based on genetic variations in target proteins, potentially leading to personalized dosing strategies and safer analgesic alternatives

doi: 10.1016/j.rbmo.2019.06.011 170 LuXWuZWangMChengW

Hrelec M, Klicek R, Brcic L, Brcic I, Cvjetko I, Seiwerth S, et al

Chemoresistance occurs when cancer cells have or develop the ability to tolerate exposure to one or more chemotherapy drugs