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Another recurring limitation emerges on antioxidant-based interventions in ASD, constrained by a fundamental methodological gap: most clinical studies report behavioral or functional improvements without directly measuring oxidative-stress biomarkers

Moreover, vascular endothelial cells in the breast cancer microenvironment release several miRNAs ( miR-142-5p , miR-183-5p , and miR-222-3p ) that are transported through extracellular vesicles, and subsequently regulate macrophage remodeling and promote macrophage polarization toward the M2 phenotype 73 ( Figure 3H )

The Trx and GSH systems are critical enzymatic systems in controlling the redox status of cysteine residues in proteins through reductive catalysis

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Importantly, using a Trx1-trapping mutant we found that the T H 17-skewing protein STAT3 is oxidized upon treatment with SFN