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This study assessed the impact of GLA, B vitamins, vitamin E, and selenium along with ALA (BETTERAL ) on the redox status of erythrocytes in 28 patients who had suffered a recent acute stroke [141]

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Using co-immunoprecipitation (CO-IP), the study confirmed that FOXO4-DRI prevents FOXO4 binding to p53, facilitating phosphorylated p53 nuclear exclusion, which triggers BAX upregulation and cleaved caspase-3 activation driving selective apoptosis of senescent endothelial cells

2015 Feb 1;278:210-20