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[11] Serious side effects may include anaphylaxis, and low blood potassium resulting in heart failure

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Because NNMT occupies a central position within nicotinamide methylation pathways, it has become an important target for investigations involving enzyme regulation, methyl-donor utilization, cofactor-associated signaling networks, and methyltransferase pharmacology

That said, if any adverse effect is suspected to be dose-related, the dose can be reduced