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Front Toxicol [Internet]

In practice, that 4.8% represents a 24-fold increase in contaminant content (5% versus 0.2%), which can dramatically affect sensitive research endpoints

In part, this reflects excitation/inhibition balance and classical aminergic neuromodulatory tone in the brain, both of which are deranged by excess nitrogen and can ultimately cause excitotoxicity if nitrogen imbalances are not promptly addressed (Rangroo Thrane et al., 2013)

Early results show up to 15% weight loss, and larger studies are expected to start soon

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