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Description

Consistent with this architecture, structural and biochemical studies identify SIRT2 as an efficient lysine delactylase capable of removing -lactyl-lysine from histone peptides/nucleosomes and reducing histone Kla in cells, although both efficiency and stereochemical bias can be substrate- and condition-dependent [64, 71]

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The inflammatory response was assessed by measuring proinflammatory cytokines such as interleukin (IL)-1, IL-6, and TNF-, and ferroptosis was assessed by analyzing MDA, GSH, GPX, and free iron (II) levels

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