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SUMMIT: Tirzepatide and heart failure with preserved ejection fraction SUMMIT (Packer et al., NEJM 2024, NEJMoa2410027, PMID 39555826) randomized 731 patients with heart failure with preserved ejection fraction (HFpEF) and a BMI 30 to tirzepatide up to 15 mg/week or placebo, with a median follow-up of 104 weeks

Its biggest results come combined with semaglutide as CagriSema

Compounded semaglutide is custom-made medication which can be helpful during shortages or when the patient needs a custom dose or formulation, but its consistency and safety are not approved by the FDA

noise exposure time two-way repeated measures ANOVA, interaction, F 1.785,10.709 = 8.100, P = 0.008

Documented anti-doping rule violations have occurred based on non-analytical findings through information gathering