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Although ROS generation may not be an essential factor for aging (Lpez-Otn et al., 2013), they are more likely to exacerbate age-related diseases progression via oxidative damage and interaction with mitochondria (Dias et al., 2013)

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Tumor necrosis factor (Tnf)-Alpha-Induced il-8 expression in gastric epithelial cells: Role of reactive oxygen species and ap endonuclease-1/Redox factor (Ref)-1