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Although G subunits have been found to play key roles in modulating canonical effectors in G proteins at the cell surface, several recent studies have revealed that G also regulates numerous molecules in distinct subcellular regions [48, 49]

This association with iron accumulation in chondrocytes is characterized by IL-1 upregulating TfR1 and DMT1 while downregulating FPN1, which exacerbates iron overload, disrupts ECM balance, and ultimately leads to cartilage damage (Jing et al., 2020

There were also some indirect evidences to demonstrate the relationship between circadian clock and pulsatile GH secretion

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Bio-Incorporation of TePhe, a Tellurium-Containing Phenylalanine Analogue, Preserves Protein Structure & Stability