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5-Amino-1MQ's mechanism centers on NNMT inhibition: NNMT inhibition : Selectively blocks NNMT with an IC50 of approximately 1.2 microM

& Kaatz, G

[7] In other words, by inhibiting this interaction, FOXO4-DRI might enhance the organisms ability to clear these cells without significantly impacting other functions of FOXO4

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Inhibition of neuronal nitric oxide synthase prevents alterations in medial prefrontal cortex excitability induced by repeated cocaine administration