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Interactions Among Endocrine Axes The activity of the insulin-GH-IGF-axis is dependent on the other endocrine axes which have permissive actions on GH stimulated IGF-I expression and affect IGFBPs and proteases (Figure 4)

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Beyond WL, these effects may be partly driven by its triple agonism, particularly glucagon receptor activation, which enhances lipid oxidation and reduces hepatic lipid synthesis [56]

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Continued investigation is exploring its potential across additional tissue types and conditions, but it is essential to keep the framing precise: animal-model and preclinical evidence is not the same as proven human therapy , and BPC-157 has not cleared the bar of FDA approval