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The mechanisms behind this increased risk are multifactorial: Iron and Estrogen Synergy: In breast tissue, iron synergizes with estrogen metabolites to generate reactive species, a process intensified in post-menopause when iron stores rise

This is why Brazil nuts are nowadays almost exclusively harvested from wild trees growing in their native habitat, and are never used for timber once grown, it is much more profitable to continuously harvest it, to the point where cutting or damaging Brazil nuts trees is illegal in Brazil

doi: 10.4049/jimmunol.164.1.176

For many patients, this means an injection once a month, but some individuals may require injections every three months