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The rational design and synthesis of TLK199 was based on the principle that modulation of drug resistance could be utilized as a viable clinical approach to cancer treatment

Bae J, Ha M, Perumalsamy H, Lee Y, Song J, Yoon T-H

However, there is still scarce in vitro evidence that sustains this possibility [61]

Discrimination index D2 = (Tnew - Tfamiliar) / (Tnew + Tfamiliar)

| Target Concentration | BAC Water to Add | Dose per 10 units on syringe | |---------------------|-----------------|------------------------------| | 10mg/ml | 3.0ml | 1.0mg | | 15mg/ml | 2.0ml | 1.5mg | | 6mg/ml | 5.0ml | 0.6mg | **Best for:** Patients on 4-12mg weekly doses who want the best cost-per-milligram value