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Many neurons signal the consequences of eating less and metabolizing more on muscle, adipose tissue, liver, and other tissues

However, most research on antioxidants is based on preclinical models, and although these results are encouraging, the application of antioxidants in a clinical setting still faces numerous challenges

It is aggravated by inflammation and the build-up of calcium or calcification inside the blood vessels

Research in Drosophila melanogaster demonstrated geroprotective effects at concentrations 16,000-80,000,000 times lower than those required for melatonin, suggesting Epithalon functions through highly efficient regulatory mechanisms rather than stoichiometric antioxidant consumption

Acta Paediatr 2005