160 The delivery of the CRISPR/Cas9 system is a crucial issue limiting its clinical application
Arginase 1 (cytosolic isoform) expression in MDSCs is also important for the suppressive function of these cells, restraining Teffs-mediated antitumor immunity and promoting both Teffs cell death and Tregs suppressive effects [85, 86]
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Some probiotic strains, such as Lactobacillus and Bifidobacterium , have been shown to reduce the production of reactive oxygen species (ROS) and enhance the activity of antioxidant enzymes (Yang et al., 2020a
