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Since IGF- 1R signaling is crucial for maintaining vascular health, interventions that enhance IGF- 1 bioavailability, improve endothelial function, or promote angiogenesis could help mitigate vascular contributions to sarcopenia

PMID: 102 SilveiraGRCGanzaroliVFToroLFLopes-PereiraECostaLLDMello-NetoJMDet al

Martinez-Curiel et al., 2025), which in some cases is not feasible due to constraints on animal experimentation protocols

By considering factors such as age, lifestyle, and specific health conditions, healthcare providers can develop customized protocols that enhance the effectiveness of these therapies

Recent evidence from preclinical studies and clinical trials underscores their therapeutic potential