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ONOO exerts its adverse effects by direct interaction with CO 2 , proteins that contain transition metal centers or thiols, or indirectly by aiding the generation of the highly potent hydroxyl radical

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This differentiated status of DMSO-treated HepaRG cell cultures was routinely checked by their phase-contrast microscopy analysis, demonstrating the presence of hepatocyte-like islands and the formation of bile canaliculi, as previously reported ( 39 )