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Kleinschnitz C, Grund H, Wingler K, Armitage ME, Jones E, Mittal M, Barit D et al (2010) Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration

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Preclinical work has demonstrated that activation of mu opioid receptors (MORs) is necessary, but not sufficient for ketamine to reduce depressive-like behaviors 17 , that ( S )-ketamine involves direct interactions with brain MORs at doses and concentrations relevant to its reinforcement and antidepressant-like efficacy 18 , and that -endorphin presence and opioid receptor activation in the mPFC may be required for ketamines antidepressant actions 19