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Rather than writing off histamine as a bystander in common allergic reactions, we must consider histamine as a primary agent for various destabilizing effects in the body and a considerable source of systemic stress
Still, it is safe to conclude that a vicious circle between liver fibrosis, cirrhosis, portal hypertension, and pathologic angiogenesis did not occur, or, once it had already advanced, there was a rapid reversal [118] (Figure 2, Table 2)
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