Shen C, Wang C, Yin Y, Chen H, Yin X, Cai Z, et al
Its levels drop dramatically when the toxic load is large Detoxifies many xenobiotics Chelator of lead, mercury, cadmium, and arsenic Prevents neuropathy from chemotherapy Maintains reduced state of other antioxidants: vitamin C & E Supports numerous metabolic and biochemical reactions: DNA synthesis and repair Protein synthesis Prostaglandin synthesis Amino acid transportation Enzyme activation Glutathione is a powerful antioxidant made in the bodys cells, using amino acids: glutamine, glycine, and cysteine
The GABA(A) receptor is a ligand-gated ion channel regulated by neuroactive steroids (96, 97)
REST directly binds to the promoter region of glutamate-cysteine ligase (GCLM), inhibits the synthesis of GSH through transcriptional inhibition of GCLM expression, and induces ferroptosis
Oral delivery concentrates the compound in the GI tract