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The physical force can damage, or denature, the fragile molecules

When compared with the respective CON-fed groups, EtOH dramatically induced hepatic protein carbonylation in both WT and KO mice, albeit the levels in the KO mice remained higher than those observed in WT mice

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For example, POD is an antioxidant enzyme that is closely associated with the biosynthesis of phenylpropanoid [24]

When the bodys antioxidant defenses, such as Glutathione, are depleted, oxidative damage can increase, and cells can become less responsive to insulin