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Side effects: generally resolved

Longer term For longer protocols, review broad health trends every 3-6 months with a clinician

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The palmitoyl group increases its logP value (lipophilicity), allowing better diffusion through the stratum corneum compared to unmodified GHK (logP 2000 mg/kg) or irritation reported in patch tests, as per Cosmetic Ingredient Review assessments

This distinction matters because pain relief through tissue repair is more sustainable than pain relief through receptor blockade