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Senescent-like microglia, in contrast, limit remyelination through SASP that involves the release of multiple inflammatory mediators, including CCL11, CXCL9, and CCL5, and increased expression of IL-2, leading to impaired remyelination in mouse models (Gross et al., 2025)

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randomized, observer-blind, placebo-controlled studies to evaluate the safety, reactogenicity and immunogenicity of an investigational non-typeable Haemophilus influenzae (NTHi) protein vaccine in adults

Because GHK-Cu seems to talk directly to fibroblasts, and because the body stocks less of it with age, fibroblasts are an obvious candidate for studying how this peptide might affect aging tissue