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According to the most recent Global Burden of Disease classification system in 2021, in the United States, Alzheimer's disease and other dementias were the 17th leading disease or injury cause of DALYs overall 482 and the leading disease or injury cause for the age group 80 years

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Senescent fibroblasts and endothelial cells, through the secretion of SASPparticularly PDGF-Apromote an increase in myofibroblast numbers at wound sites, which positively affects wound healing [141]

Benesch et al., 2007)