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Proteomaps (www.proteomaps.net) based on RNA transcript data were drawn to visualise three levels of functional categories based on KEGG pathway analysis (www.genome.jp/kegg/) (29) Analysis of immune cell infiltration and the glandular microenvironment The cell type of each cluster (43 immune cells and 8 salivary glandular compositions) was identified using the CellMarker database and by aligning marker genes to known signature genes reported in previous studies (30)

As the only extracellular enzyme in the GPx family, GPx3 is an essential enzyme that is responsible for removing ROS products during normal metabolism or oxidative damage in healthy tissues [76]

Another widespread pollutant is N,N-diethyl-3-methylbenzamide (DEET), the most widely used insect repellent in the world