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In cynomolgus monkeys, intra-ovarian injection of human embryonic stem cellderived MSC-like M cells reduced fibrosis and DNA damage, restored sex-steroid secretion, and supported the birth of a healthy infant, changes substantiated by single-cell RNA sequencing that showed dampened oxidative stress and inflammation in granulosa and stromal compartments [192]

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Exendin-4 inhibits interleukin-1beta-induced iNOS expression at the protein level, but not at the transcriptional and posttranscriptional levels, in RINm5F beta-cells