Individuals with an IBS diagnosis should be particularly skeptical about novel therapeutics that have a long list of potentially adverse impacts
Accordingly, Weiss and coworkers performed a series of experiments to examine the effect of selenium administration (single intraperitoneal injection) through sodium selenite (1.6 mg/kg body weight) or SeM (0.8 to 4 mg/kg body weight) on improving the 30-day survival of mice against lethal doses (910 Gy) of whole body -irradiation (WBI) (Table 2) [42,43,44]
Prieto L, Quesada JF, Cambero O, et al
However, this approach faces several challenges, including the potential for the blood-brain barrier (BBB) to mask or dilute CNS-specific signals and the difficulty in distinguishing brain-derived markers from those originating systemically (87,88)
The methodological quality of the included studies, as assessed through the Jadad and NewcastleOttawa scales, varied from moderate to high, while the GRADE assessment indicated moderate certainty of evidence for serum vitamin B12 increase and low certainty for homocysteine reduction