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The levels of p-STAT3 and STAT3 significantly increase, leading to overexpression of cyclooxygenase-2 (COX-2) and COX-2 mRNA, indicating that H 2 S can decrease cell apoptosis through the STAT3/COX-2 signaling pathway and promote the progression of HCC

Under pathological conditions such as PD, astrocyte function becomes profoundly altered, significantly influencing neuronal susceptibility to ferroptosis

Thats because glutathione is a triple threat to toxins: It neutralizes free radicals, enhances the immune system, and detoxifies the liver

These findings have important clinical ramifications with the possibility of targeting ferroptosis pathway in GPX4-overexpressing thyroid cancers