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The authors of one trial (95) included in the above-mentioned meta-analysis (89) noted that little cognitive decline was observed in the placebo group over their two-year trial, which may have limited their power to detect an effect of the B-vitamin intervention (95)

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Blocks the NNMT enzyme that converts nicotinamide to N-methylnicotinamide, preserving nicotinamide for NAD+ synthesis and cellular energy pathways

These names refer to the same 15-amino-acid sequence