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First, current research on ferroptosis has only touched on the phenomenon, and the detailed roles of ferroptosis in the onset and development of human diseases have not been deeply studied, posing a challenge for precision medicine

[7] Genetics: Variations in genes like NAMPT which helps convert nicotinamide into NMN affect how efficiently your body processes precursors

The main challenge with oral supplementation is that glutathione is broken down in the digestive system before it can reach the brain

doi: 10.1016/j.amsu.2021.102406