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3.1 Traditional drug therapy Methotrexate is the most commonly used DMARD due to its low cost and decades of clinical experience, and considered as the gold standard drug for RA treatment ( Glucocorticoids have potent anti-inflammatory and immunosuppressive effects, and have been used to treat the acute phase of RA ( NSAIDs are one of the main therapeutic agents to alleviate the symptoms of RA

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When hydroxocobalamin is given in high doses (such as during cyanide poisoning treatment), unique effects can be observed: patients often experience a transient reddening of the skin or mucous membranes and a reddish discoloration of the urine due to drug excretion

10.1016/j.ijbiomac.2023.127162 30 BanksB